CINRYZE as a Donor Pre-treatment Strategy in Kidney Recipients of KDPI>60%

Inclusion Criteria for Kidney Recipient: * Adult patients receiving a kidney from a donor with KDPI\>60% * Provide written informed consent. * Accepted for renal transplantation due to end stage renal disease (Chronic Kidney Disease Stage V). * Recipient of a first or second renal transplant. * For second renal transplantation, minimum 3 months since the loss of the first transplanted kidney. * At least 18 years of age: If female, patient must be/have: * Post-menopausal, defined as the absence of menses for at least one year (serum FSH ≥20I U/L can also be measured according to local practice), OR Surgically sterile, defined as a bilateral tubal ligation at least 6 months prior to administration of study drug, bilateral oophorectomy, or complete hysterectomy, OR Using an effective means of contraception (per Appendix 1) that is planned to continue for the duration of the study (one year), AND negative urine pregnancy test if the patient is capable of providing a urine sample. If not capable to provide urine sample, serological pregnancy test will be perform. * Female patients of childbearing potential who are anuric must have a serum pregnancy test. If male, patient must: * Agree to use an effective means of contraception (per site-specific guidelines) that is planned to continue for the duration of the study (6 months). * Agree not to donate sperm until 6 months after dosing. Patients must be willing to comply with the protocol procedures for the duration of the study, including scheduled follow-up visits and examinations. Inclusion Criteria for Liver Recipients\*: * Provide written informed consent. * Accepted for liver transplantation * Recipient of a first liver transplant. * At least 18 years of age: If female, patient must be/have: * Post-menopausal, defined as the absence of menses for at least one year (serum FSH ≥20I U/L can also be measured according to local practice), OR * Surgically sterile, defined as a bilateral tubal ligation at least 6 months prior to administration of study drug, bilateral oophorectomy, or complete hysterectomy, OR * Using an effective means of contraception (per Appendix 1) that is planned to continue for the duration of the study (one year), AND negative urine pregnancy test if the patient is capable of providing a urine sample. If not capable to provide urine sample, serological pregnancy test will be perform. * Female patients of childbearing potential who are anuric must have a serum pregnancy test. If male, patient must: * Agree to use an effective means of contraception (per site-specific guidelines) that is planned to continue for the duration of the study (one year). * Agree not to donate sperm until 6 months after dosing. * Willingness to comply with the protocol procedures for the duration of the study, including scheduled follow-up visits and examinations. The criteria for enrollment in the study was originally limited to kidney donors with KDPI \>85%. Over the last five years however, we have only transplanted a handful of those patients If we further restrict our patient pool to those who are not liver donors, our pool of possible donors will become even smaller, making the study very difficult, if not impossible, to complete. Furthermore, our knowledge of the pathophysiology of the complement system suggests that use of C1Inhibitor will improve liver outcomes by blunting the inflammatory response which can cause liver fibrosis and reperfusion injury. Since we have seen no negative effects on the liver in our preliminary non-human primate data, there is no need to exclude possible liver donors from our treatment. Therefore, in order to increase feasibility of the study, we have now expanded the trial to include donors with a KDPI above 60% (rather than \> 85%), since the rate of DGF in recipients of kidneys from KDPI between 60% and 85% is similar to the group \>85%. In addition, we are now including liver recipients in the study, and will consent them if the donor has a viable liver in addition to the kidney(s). If we were to only include patients with KDPI above 85%, and kidney only donors, this trial would not be feasible. Exclusion Criteria: * Use of an investigational drug in the 30 days before surgery. * Participation in any other research study (drug or non-drug) without prior approval from the Medical Monitor. * Known hypersensitivity to human monoclonal antibodies or any of the study drug excipients. * Previous hypersensitivity to basiliximab, Campath-1H or antithymocyte globulin (ATG) * History of or known HIV, HBV (surface antigen), or HCV positivity * History of malignancy within the last five years, except excised squamous or basal cell carcinoma of the skin, or cervical intraepithelial neoplasia. * Scheduled to undergo multi-organ transplantation. * Presence of clinically significant infections requiring continued therapy. * Positive screening for active tuberculosis. * Existence of any surgical or medical condition, other than the current transplantation which, in the opinion of the investigator, might significantly alter the distribution, metabolism or excretion of study medication. * History or presence of a medical condition or disease that in the investigator's assessment would place the patient at an unacceptable risk for study participation. * Lactating or pregnant woman. * Patient institutionalized by administrative or court order. * HLA or ABO incompatible kidney defined as a positive cytotoxic crossmatch, positive mean fluorescent intensity beyond the acceptable parameters by the institution, or flow crossmatch-based assay that is positive (for kidney recipients only) Exclusion Criteria for Brain Dead Donor: * Donor who is known to have received an investigational drug for I-R injury or graft rejection (immunosuppressant) in the 48H prior to organ recovery * Participation in any other research study (drug or non-drug) without prior approval from the PI * Donor institutionalized by administrative or court order * Donors whose organs are allocated for transplantation to other transplant programs outside UW * Donors for which any of the intended organ recipients has not provided consent for the study * Donors that are donating other organs outside the scope of the study (i.e. heart, lungs, intestine) will be excluded.