Correlation Between Serum Anti-Müllerian Hormone & Müllerian Ducts Anomalies in Infertility

Ahmed M.Kamel226 enrolled

Overview

Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance, is a dimeric glycoprotein that belongs to the transforming growth factor-beta family. It is involved in the regression of the Müllerian ducts during male fetal development. In the female, AMH is solely produced by the granulosa cells of preantral and small antral follicles, and regulates ovarian activity and follicular steroidogenesis

Following approval of the internal review board of Egyptian IVF-ET center, a retrospective analysis will be undertaken where a detailed review of the patients files who underwent intracytoplasmic sperm injection (ICSI) trials starting January 2010 till January 2015 will be done. Patients with diagnosed mullerian anomalies will have their name , age ,duration of infertility, serum FSH, LH ,\& AMH levels recorded. The method of diagnosis (HSG, 3D/ultrasonography, hysteroscopy, or laparoscopy) will also be documented.

Study Type

OBSERVATIONAL

Enrollment

226

Conditions

Infertility

Interventions

Anti Mullerian hormone level; Mullerian duct anomaly typeOTHER

Diagnosis of Mullerian duct anomaly type Clinically or by Imaging Anti-Müllerian Hormone levels

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women with diagnosed mullerian anomlies whether clinically or through imaging Exclusion Criteria: * previous ovarian surgery * ovarian drilling * polycystic ovarian syndrome (PCOs).

Locations (1)

The Egyptian IVF-ET Center

Cairo, Maadi, Egypt

Outcomes

Primary Outcomes

Correlation of serum anti-Müllerian hormone (AMH) level with mullerian anomalies

Time frame: 2 years

Data from ClinicalTrials.gov

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