The primary objective is to develop an in vitro model of cancer for laboratory study using liver, biliary and pancreatic cancer tissue. The secondary objective is to study the genetic and cellular biology of cancer of the liver, biliary tract and the pancreas. As well the investigators hope to compare molecular and cellular biology of cancer cells with normal cells as well as potentially test the efficacy of current and future anti-cancer therapies. Samples will be collected from tissue that has been resected as part of the treatment for a patient diagnosed with liver, bile duct or pancreas cancer.
Study Type
OBSERVATIONAL
Enrollment
75
Generation of 'organoids' using in vitro culture techniques, genomic DNA and RNA sequencing, application of genome editing technology, investigation of anti-tumour drugs, investigation of biological and functional properties of tumour cells, transplantation of organoid lines into animal models.
Addenbrooke's Hospital
Cambridge, United Kingdom
RECRUITINGNumber of tumour-derived organoids successfully cultured in vitro for a minimum of 3 months.
Time frame: 3 years
Proportion of tumour-derived organoids that are genetically identical to the source tumour.
Time frame: 3 years
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