This study evaluates the impact of autologous 'leucocyte and platelet rich fibrin' (L-PRF) on the periapical bone healing and further root development of infected immature permanent teeth. In the test group regenerative endodontic procedure (REP) is performed with L-PRF as scaffold, in the control group REP without L-PRF is performed .
Regenerative endodontic procedures are biologically based procedures designed to restore function of a damaged and nonfunctioning pulp by stimulation of existing stem and progenitor cells present in the root canal and/or the introduction and stimulation of new stem and dental pulp progenitor cells into the root canal under conditions that are favorable to their differentiation and reestablishment of function. L-PRF has the potential advantage of creating a bioactive construct that stimulates the local environment for differentiation and proliferation of these stem and progenitor cells. We have designed this confirmatory study to test the hypothesis that the use of L-PRF in REP of infected permanent immature teeth will accelerate periapical bone healing and stimulate the root maturation.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
29
Megabite Dental Office
Brussels, Belgium
C-Endo
Herent, Belgium
Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven
Leuven, Belgium
EndoVanGorp
Rotselaar, Belgium
Amount of periapical bone healing, measured on intra-oral bidimensional radiographs.
Time frame: 3 years
Amount of root development or maturogenesis,by measuring:
on intra-oral bidimensional radiographs: the increase in root canal wall thickness.
Time frame: 3 years
Amount of root development or maturogenesis,by measuring:
on intra-oral bidimensional radiographs: the increase in root canal length.
Time frame: 3 years
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