PF-05212384 (PKI-587) for t-AML/MDS or de Novo Relapsed or Refractory Acute Myeloid Leukemia (AML) (LAM-PIK)

Inclusion Criteria: 1. Patients belong to one of three categories: * Myeloid neoplasm secondary to chemo-radiotherapy (t-AML/MDS) aged 60 and over with unfavorable cytogenetics (European Leukemia Network definition 2010), the first cancer must have been in remission for more than two years, except in situ carcinoma, basal cell carcinoma and squamous cell carcinoma * Relapsed or refractory de novo AML aged 18 and over (multiple relapses allowed), regardless of the risk group, provided not being eligible for allogeneic bone marrow transplantation * de novo AML at diagnosis, aged 60 and over and considered unfit to benefit from induction chemotherapy associated with aplasia (at the discretion of the investigator) 2. Adequate glycemic balance defined by glycated hemoglobin ≤ 8% 3. Females of childbearing potential (FCBP) should receive effective contraception: a negative pregnancy blood test is required within 2 weeks before starting experimental treatment. 4. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤ 2 5. Absence of severe or active infection 6. Adequate systolic cardiac function : Left Ventricular Ejection Fraction (LVEF) ≥ 50% 7. Adequate hepatic function: Aspartate Aminotransferase Test (AST) and Alanine Aminotransferase Test (ALT) ≤ 3 times the upper limit of normal (ULN), bilirubin ≤ 1.5 x ULN 8. Adequate renal function: serum creatinine ≤ 1.5 x ULN or calculated creatinine clearance \> 60 ml/min. 9. Signed informed consent Exclusion Criteria: 1. Glucose intolerance or diabetes mellitus, treated or untreated 2. First cancer in evolution(solid tumor or lymphoma) or in remission for less than two years, except in situ carcinoma, basal cell carcinoma and squamous cell carcinoma 3. AML secondary to MDS or myeloproliferative syndrome (WHO 2008 definitions) 4. Acute Promyelocytic Leukaemia (APL or AML French American British (FAB) classification 3) de novo or secondary to treatment (t-APL) 5. de novo or secondary Core Binding Factor (CBF)/AML 6. de novo or secondary Philadelphia Chromosome (Ph) 1 positive AML defined by the presence of a t(9.22) or a Breakpoint Cluster Region-Abelson Murine Leukemia Viral Oncogene Homolog (BCR-ABL) transcript 7. Leukocytes above 30.000/mm3 (30 G/L) at enrollment 8. Antileukemic treatment within 15 days before enrollment, with the exception of hydroxyurea 9. Central nervous system leukemic involvement 10. Pregnant or lactating women, or women of childbearing potential without effective contraception 11. Prior history of allogeneic bone marrow transplantation 12. Prior history of organ transplantation or other cause of severe or chronic immunodeficiency Human 13. Seropositivity for Human Immunodeficiency Virus (HIV) or Human T-Lymphotropic Virus-1 (HTLV-1) viruses, active B or C hepatitis 14. Inclusion in another experimental anti-cancer clinical trial\* 15. Patients unable to undergo medical monitoring for geographical, social or psychological issues 16. Patient under measure of legal protection 17. No social security * For ethical reasons, the exclusion period before considering the possibility of participating in another clinical study with a new experimental molecule cannot be determined, yet each case will be discussed on an individual basis with the study coordinator.