Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy (KETOCOL-1304)

Inclusion Criteria: * Patient with a uterine cervical cancer or an upper aero-digestive tract cancer * Age ≥ 18 years and ≤ 75 years * Patient who are eligible for brachytherapy treatment associated with or without hospital stay * With operative procedure under general anesthesia to set up the material needed for brachytherapy * Performance status ≤ 2 * Creatinine Clearance ≥ 60 ml/min using Cockcroft equation * No coagulation disorder or anticoagulation therapy at curative dose * Registered with a social security system * Patient having dated and signed an informed consent form before initiation of any study procedures Exclusion Criteria: * Respiratory pathology (SpO2\< 70 %) * Severe undernutrition * Previous hypersensitivity reactions such as bronchospasm, asthma, rhinitis, hives or other allergic reaction to ketoprofen, to acetylsalicylic acid, or other NSAIDs * Previous hemorrhage or gastrointestinal perforation during a previous treatment with NSAID * Gastrointestinal hemorrhage , cerebrovascular hemorrhage or other evolutive hemorrhage * Evolutive peptic ulcer, previous peptic ulcer or recurring hemorrhage (2 or more distinct episodes of hemorrhage or ulcer objectified) * Liver insufficiency * Severe renal insufficiency * Severe heart failure * Treatment with another NSAID, including selective cyclooxygenase-2 inhibitors * Intolerance or hypersensitivity to one of the treatments or excipients * Inability to swallow * Pregnant or breastfeeding woman * Patient under tutorship or guardianship