Efficacy and Safety of JM-010 in PD With Levodopa-Induced Dyskinesia

Inclusion Criteria: * Written informed consent. * Subject with a diagnosis of moderate to severe idiopathic PD with showing responsiveness to levodopa. * All anti-Parkinsonian medications and levodopa must be stable for at least 1 week prior to the start of the run-in period. * Subject with stable predictable peak-effect LID of at least 2 hours of the awake day and with at least moderately disabling. * Amantadine and/or monoamine oxidase (MAO) inhibitor must be stopped at least 2 weeks prior to the start of Treatment Period 1(TP 1). Exclusion Criteria: * Diagnosis is unclear or a suspicion of other Parkinsonian syndromes exists, such as secondary Parkinsonism, Parkinson-plus syndromes or other neurological degenerative diseases. * History of any other brain surgery or surgery for the treatment of PD. * Current primary psychiatric diagnosis of acute psychotic disorder or other primary psychiatric diagnoses. * A history of psychosis and/or treatment with antipsychotics within 3 months prior to the start of Treatment Period 1(TP1). * A history of, or current, seizure disorders and subjects requiring treatment with anti-convulsants. * Clinically significant abnormal laboratory data at screening. * Clinically relevant ischemic heart symptoms or history of myocardial infarction, coronary artery bypass surgery or percutaneous transluminal coronary angioplasty, within the previous 12 months prior to the start of TP1. * History of cerebrovascular accident or transient ischemic attack, coronary vasospasm/Prinzmetal's angina. * History of serotonin syndrome. * Breast feeding or pregnant women.