Comparison of Effects of PEEP Levels on Respiratory Mechanics in Patients Undergoing Laparoscopic Cholecystectomy

Umraniye Education and Research Hospital75 enrolled

Overview

Laparoscopic cholecystectomy is accepted as gold standard in the management of cholelithiasis. Although laparoscopic procedures have many advantages,intra-abdominal CO2 insufflation can cause decreased lung volumes and compliance, increased airway resistance and impaired ventilation-perfusion ratio. In this study, investigators aim to investigate effects of intra-operative PEEP treatment at 3 distinct levels on respiratory dynamics and elimination time of volatile anesthetic agent.

In the study, 75 ASA I-II patients aged 30-65 years will be randomized into 3 groups to receive 0 cmH2O PEEP (Group-1), 5 cmH2O PEEP (Group-2) and 8 cmH2O PEEP (Group-3) in PVC mode. In all patients underwent general anesthesia; hemodynamic parameters, Ppeak, Pplateau, compliance values as well as Fisevo/Fexpsevo ratio at 1 MAC and times from 1 MAC to 0.3 and 0.1 MAC will be recorded. In addition, preoperative and postoperative pulmonary function tests will be compared in all patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Respiratory System Abnormalities

Interventions

PEEP 0PROCEDURE

0 cmH2O positive end expiratory pressure

PEEP 5PROCEDURE

5 cmH2O positive end expiratory pressure

PEEP 8PROCEDURE

8 cmH2O positive end expiratory pressure

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ASA (American Society of Anesthesiologists) I-II * BMI of 25-30 * patients scheduled to elective laparoscopic cholecystectomy. Exclusion Criteria: * Patients with ASA III, IV, V risk, * Patients with comorbid diseases that may increase intra-abdominal pressure or pulmonary hypertension, * Patients with renal and hepatic failure, * Patients with pregnancy and * Patients using bronchodilator or steroid were excluded.

Locations (1)

Istanbul Umraniye Training Hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

levels of static-dynamic compliance with intra-operative PEEP treatment at 3 distinct levels

Time frame: 1 month

Secondary Outcomes

elimination time of volatile anesthetic agent with intra-operative PEEP treatment at 3 distinct levels

Time frame: 1 month

levels of p peak and p plateau pressures with intra-operative PEEP treatment at 3 distinct levels

Time frame: 1 month

Data from ClinicalTrials.gov

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