This is a study to provide an in-depth validation of the 1-minute sit-to-stand test as a measure of exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Patients will perform the 1-minute sit-to-stand test and other validated exercise tests and questionnaires.
Exercise capacity is a strong predictor for mortality, exacerbations and health-related quality of life (HRQL) in patients with chronic obstructive pulmonary disease (COPD). The 1-minute sit-to-stand test (1-min STS test) is a promising exercise capacity test that is simple to conduct and requires few resources. This study will provide an in-depth validation of the 1-min STS test, specifically evaluating the tests reliability, validity, responsiveness to change and minimal clinically important difference. The study will also assess the predictive properties of the 1-min STS test with regards to detecting exacerbations, as well as identify patterns of physical activity and patient-reported symptoms of exacerbations.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
55
Validation of the 1-minute sit-to-stand test in a COPD patient population
University of Zurich
Zurich, Switzerland
1-minute sit-to-stand test
Number of repetitions performed in the 1-minute sit-to-stand test
Time frame: Change from baseline after pulmonary rehabilitation programme
5-repetition sit-to-stand test
Time taken to perform 5 sit-to-stand repetitions
Time frame: Change from baseline after pulmonary rehabilitation programme
6-minute walk test
Distance walked in 6 minutes
Time frame: Change from baseline after pulmonary rehabilitation programme
Quadriceps maximal voluntary contraction force
Time frame: Change from baseline after pulmonary rehabilitation programme
Chronic Respiratory Questionnaire
Time frame: Change from baseline after pulmonary rehabilitation programme
Hospital Anxiety and Depression Scale
Time frame: Change from baseline after pulmonary rehabilitation programme
COPD Assessment Test
Time frame: Change from Baseline after pulmonary rehabilitation programme
Baseline Dyspnoea & Transition Dyspnoea Index
Time frame: Change from baseline after pulmonary rehabilitation programme
Feeling Thermometer
Time frame: Change from baseline after pulmonary rehabilitation programme
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Oxygen consumption (VO2)
Time frame: Change from baseline (pre-exercise test) during and after test
Carbon dioxide production (VCO2)
Time frame: Change from baseline (pre-exercise test) during and after test
Respiratory exchange ratio (RER)
Time frame: Change from baseline (pre-exercise test) during and after test
Minute ventilation (VE)
Time frame: Change from baseline (pre-exercise test) during and after test
Heart Rate
Time frame: Change from baseline (pre-exercise test) during and after test
Blood oxygen saturation
Time frame: Change from baseline (pre-exercise test) during and after test
Symptoms of exacerbations
The EXAcerbations of Chronic Pulmonary Disease Tool (EXACT)
Time frame: Daily course over 3 months
Physical activity
As measured by a pedometer
Time frame: Daily course over 3 months
Localisation
As measured by GPS information
Time frame: Daily course over 3 months