The investigators aimed at evaluating the metabolic effects of the inversion of the typical Italian sequence of food ingestion at the main meals in type 2 diabetic patients.
An intervention group follows a modified diet over a period of two months in which the ingestion of protein and lipid happens before that of carbohydrates. A control group follows a standardized diet in which the ingestion of carbohydrates happens before that of protein and lipid. Both diets contain a reduced intake of high-glycemic index meals, saturated fatty acids, trans fatty acids and alcohol. On four days separated by one month each other (two before the beginning of the diet and two after 1 month and 2 months of diet) we measure clinical and metabolic parameters (weight, waist and hip circumferences, glucose, glycated hemoglobin, fructosamine, lipid profile) to compare the effects of the two diets.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Two months of a diet in which the ingestion of protein and lipid precedes that of carbohydrates.
Two months of a diet in which the ingestion of protein and lipid follows that of carbohydrates.
Azienda Ospedaliero-Universitaria Pisana
Pisa, PI, Italy
RECRUITINGChange from baseline fructosamine after 1 and 2 months of diet
Fructosamine will be measured.
Time frame: On four days separated by one month each other (two before the beginning of the diet and two after 1 month and 2 months of diet)
Change from baseline fasting plasma glucose after 1 and 2 months of diet
Fasting plasma glucose will be measured.
Time frame: On four days separated by one month each other (two before the beginning of the diet and two after 1 month and 2 months of diet)
Change from baseline glycated hemoglobin after 1 and 2 months of diet
Glycated hemoglobin will be measured.
Time frame: On four days separated by one month each other (two before the beginning of the diet and two after 1 month and 2 months of diet)
Change from baseline weight after 1 and 2 months of diet adipose tissue location
Waist circumference and hip circumference will be measured.
Time frame: On four days separated by one month each other (two before the beginning of the diet and two after 1 month and 2 months of diet)
Change from baseline adipose tissue location after 1 and 2 months of diet
Weight, waist circumference and hip circumference will be measured.
Time frame: On four days separated by one month each other (two before the beginning of the diet and two after 1 month and 2 months of diet)
Change from baseline lipid profile after 1 and 2 months of diet
Lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) will be measured.
Time frame: On four days separated by one month each other (two before the beginning of the diet and two after 1 month and 2 months of diet)
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