Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity

Inclusion Criteria: 1. Newly diagnosed tumours classified as stage T2-4 N0-2 (TNM 7th edition 2009) located in the larynx, oropharynx or hypopharynx (unknown primary and oral cavity are not eligible) 2. Histopathological diagnosis of invasive squamous cell carcinoma in the primary tumour 3. Decision for curative intent external beam radiotherapy with elective treatment of the neck made by a multidisciplinary head-and-neck oncology team. The patient must be expected to complete the treatment. 4. Radiotherapy planned to start within 6 weeks from baseline imaging of tumour assessment 5. No distant metastasis (M0) (TNM 7th edition 2009) 6. WHO performance status 0-2 7. ≥ 18 years of age 8. Written informed consent Exclusion Criteria: 1. Concomitant chemotherapy or EGFR inhibitors for this tumour. 2. Primary tumour of the oral cavity or unknown primary tumour 3. Prior or current anticancer treatment to the head and neck area (e.g. radical attempted or tumour reductive surgery, neo-adjuvant or concomitant chemotherapy, EGFR inhibitors or radiotherapy), except for endoscopic glottic laser micro surgery. 4. Current participation in any other oncologic interventional clinical study for this tumor. 5. Uncontrolled diabetes mellitus. 6. Known or suspected HIV infection. 7. History of previous malignancy within the last 3 years, with the exception of surgically cured carcinoma in situ of the cervix, in situ breast cancer, incidental finding of stage T1a or T1b prostate cancer, basal/squamous cell carcinoma of the skin, and other non-invasive malignancies (e.g. in situ carcinomas).. 8. Any condition (somatic, psychological, familial, sociological or geographical) rendering the patient unable to understand or complete questionnaires.