The purpose of the present study is to gather pilot data on the effects of linagliptin on the concentration of the long and short forms of SDF1-α (stromal cell-derived factor alpha) in humans, and to demonstrate the feasibility of such a study in patients with psychosis in our setting.
This study is a 13-week, open-label study of 8 participants with schizophrenia and minimal thought disorder; they will have 12 weeks of treatment and week for assessment. They will receive linagliptin, 5 mg by mouth once per day, while continuing their antipsychotic treatment. The principal outcome measures will be the concentrations of the long and short forms of SDF1-α (stromal cell-derived factor alpha) in blood.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
10
12 weeks of treatment and week for assessment. Linagliptin, 5 mg by mouth once per day for 12 weeks, in combination with continued antipsychotic treatment.
University of Nevada School of Medicine
Reno, Nevada, United States
SDF1-α (stromal cell-derived factor alpha) Concentration
Time frame: Blood will be collected on the first week and then biweekly for 12 weeks.
DPP-4 (Dipeptidyl peptidase-4) Activity
Time frame: Blood will be collected on the first week and then biweekly for 12 weeks.
Monocyte State
Flow cytometry will be used to examine the state of monocytes to look for cells recently arrived from the bone marrow and to examine the polarization (pro-inflammatory vs. anti-inflammatory) of the monocytes
Time frame: Blood will be collected on the first week and then biweekly for 12 weeks.
Absolute/Differential leukocyte count
Flow cytometry will be used.
Time frame: Blood will be collected on the first week and then biweekly for 12 weeks.
CD271+ cells
Flow cytometry will be used to detect CD271+ cells.
Time frame: Blood will be collected on the first week and then biweekly for 12 weeks.
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