Non-invasive Measurement of Cerebral Dynamic Autoregulation

University of Pennsylvania21 enrolled

Overview

The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors. Optical cerebral blood flow measurements will be correlated with changes in arterial blood pressure to assess how CBF is maintained in response to changes in ABP, and will be compared to transcranial doppler reference measurements.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Stroke

Interventions

Thigh CuffDEVICE

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age greater than or equal to 50 years * Positive history of at least one of the following vascular disk factors: hypertension, diabetes, hyperlipidemia, coronary artery disease, atrial fibrillation, prior myocardial infarct, transient ischemic attack, or history of smoking Exclusion Criteria: * Vascular risk factor subjects: 1. Pregnant women 2. Prisoners 3. Prior neurosurgical procedure or traumatic brain injury, including hemicraniectomy or other skull defect 4. Prior history of ischemic or hemorrhagic stroke 5. Prior lower extremity amputation 6. Peripheral vascular disease

Locations (1)

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

dCA Measurement During Acute Changes in Mean Arterial Pressure, TCD

Rate of Regulation, measured using transcranial doppler. Rate of regulation (ROR) is calculated as follows: ROR = (change in relative cerebrovascular resistance / change in time) / maximum fractional decrease in blood pressure due to thigh cuff deflation.

Time frame: 1.5 hours

dCA Measurement During Acute Changes in Mean Arterial Pressure, Optical

Rate of Regulation, measured using diffuse correlation spectroscopy. Rate of regulation (ROR) is calculated as follows: ROR = (change in relative cerebrovascular resistance / change in time) / maximum fractional decrease in blood pressure due to thigh cuff deflation.

Time frame: 1.5 hours

Data from ClinicalTrials.gov

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