Evaluation of Paternal, Maternal and Obstetric Factors Leading to the Hepatitis B Immunization Failure in Hong Kong

The University of Hong Kong750 enrolled

Overview

Globally, hepatitis B virus (HBV) infection is the most common form of chronic hepatitis. There are still a lot of uncertainties on how infants acquired HBV leading to the development of chronic HBV infection despite active and passive immunoprophylaxis. The investigators would like to carry out a prospective study to answer the following questions: 1. the paternal, maternal and obstetric factors leading to immunoprophylaxis failure 2. the prevalence of immunoprophylaxis failure in Hong Kong

Study Type

OBSERVATIONAL

Enrollment

750

Conditions

Hepatitis B Infection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All women age ≥ 18 years * Maternal or paternal hepatitis B carrier Exclusion Criteria: * Couples will be excluded if female partners of paternal hepatitis B carrier were occult carrier * Plan to deliver in other units

Locations (1)

Department of Obstetrics and Gynaecology

Hong Kong, Hong Kong, China

Outcomes

Primary Outcomes

The effect of high maternal viral load on immunoprophylaxis failure, using 10^6 copies/ml as cut-off

Time frame: Infants' blood for HbsAg at 9-12 months old

Data from ClinicalTrials.gov

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