gliomasPCV Only in 1p/19q Codeleted Anaplastic Gliomas

Inclusion criteria : Histological confirmation of anaplastic glioma by central pathological review * Tumor is co-deleted for 1p and 19q * Age ≥ 18 years of age * Newly diagnosed and ≤3 months from surgical diagnosis * Willing and able to complete neurocognitive examination and the QOL * Karnofsky performance status ≥ 60 * The following laboratory values obtained ≤ 21 days prior to registration: * Absolute neutrophil count (ANC) ≥1500 /mm3 * Platelet count ≥100,000 / mm3 * Hemoglobin \> 9.0 g/dL * Total bilirubin ≤ 1.5 x upper limit of normal (ULN) * SGOT (AST) ≤ 3 x ULN * Negative serum or urine pregnancy test done ≤ 7 days prior to registration, for women of childbearing potential only. * Provide informed written consent Exclusion criteria : * Pregnant and nursing women * Men or women of childbearing potential who are unwilling to employ adequate contraception during this study and for up to 6 months following the completion of PCV. * Received any prior radiation therapy or chemotherapy for any CNS neoplasm.