This study aims to identify clinical and biological markers which would allow to evaluate precisely the evolution of children with autism spectrum disorders throughout intervention.
200 children with autism spectrum disorders (1-12 years old) will be included in a 2 years follow-up study. Both clinical and neurophysiological evaluations (electrophysiological and eye tracking) will be completed at different times of the follow-up. This integrative approach, combining clinical and biological markers, will allow the identification of different developmental trajectories and then a better individuation of treatment in autism spectrum disorders.
Study Type
OBSERVATIONAL
Enrollment
200
University hospital Tours
Tours, France
Clinical changes between Baseline and Two years
Autism Diagnostic Observation Schedule (ADOS)
Time frame: 2 years
neurophysiological evaluations at baseline
Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices
Time frame: baseline
neurophysiological evaluations at 1 year
Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices
Time frame: 1 year
neurophysiological évaluations at 2 years
Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices
Time frame: 2 years
Social and cognitive evaluations at baseline
Social and Cognitive Evaluation Battery (SCEB),
Time frame: baseline
Social and cognitive évaluations at 1 year
Social and Cognitive Evaluation Battery (SCEB),
Time frame: 1 year
Social and cognitive évaluations at 2 years
Social and Cognitive Evaluation Battery (SCEB),
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Time frame: 1 year
Repetitive behaviors évaluations at baseline
Repetitive and Restrictive Behavior Scale (RRBS)
Time frame: baseline
Repetitive behaviors évaluations at one year
Repetitive and Restrictive Behavior Scale (RRBS)
Time frame: 1 year
Repetitive behaviors at two years
Repetitive and Restrictive Behavior Scale (RRBS)
Time frame: 2 years