High-intensity Interval Training in Overweight/Obese

University of North Carolina, Chapel Hill76 enrolled

Overview

Purpose: The purpose of this study would be to evaluate the effects of interval training on cardiovascular health, lipid profile and body composition in overweight and obese men and women. A secondary purpose will be to compare lab based measurements of body composition \[4-compartment model (4C)) with portable equipment \[bioelectrical impedance spectroscopy (BIS) and ultrasound (US)\] Participants: Seventy-six men and women (age 18-55 yrs; BMI 25-45 kg/m2) will be randomly assigned to a high-intensity short interval group (SIT), high-intensity long interval group (HIT) or a control group (CON). Procedures (methods): Participants will be assessed for peak oxygen utilization (VO2peak), blood lipids, glucose and insulin levels. Body composition will also be measured using a 4C model, as measured from dual energy x-ray absorptiometry (DEXA), air displacement plethysmography (BodPod), and BIS, in comparison to US values. Participants assigned to either training group will undergo 3 weeks of interval training, 3 days per week. SIT will complete 10 bouts of a series of 1 min cycling with 1 min rest periods at 90% of the power output obtained during VO2peak;in comparison HIT will complete 5 bouts of the same protocol: 2 min bouts with 1 min recovery at varying intensities of VO2peak (80-100% power output).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Obesity, Metabolically Benign

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * written and dated informed consent to participate in the study. * willing and able to comply with the protocol. * good health as determined by a health and exercise status questionnaire * normal electrocardiogram (ECG), and physical. * body mass index of 25-45 kg/m 2. * has been cleared for participation by a physician (either study or personal). Exclusion Criteria: * participating in another clinical trial or have received an investigational product within thirty days prior to enrollment. * has lost ten or more pounds during the previous three months and maintained the weight loss. * significant history or current presence of untreated high blood pressure (BP) \[systolic BP\> 140 mmHg and/or diastolic BP\> 90 mmHg\], thyroid disease, tachyarrhythmia, heart disease, kidney disease, or liver disease. Subject currently suffers from/or has a known history of (or is currently being treated for) clinical depression or an eating disorder(s). * has any medical condition or uses any medication, nutritional product, dietary supplement or program, which in the opinion of the investigator, might interfere with the conduct of the study or place the subject at risk. * are identified as moderate to high risk individuals by the American College of Sports Medicine will be excluded from the study.

Outcomes

Primary Outcomes

Cardiorespiratory Fitness (VO2peak)

Time frame: 3 weeks

Secondary Outcomes

Body Composition

Time frame: 3 weeks

Blood Lipids

Time frame: 3 weeks

High-intensity Interval Training in Overweight/Obese

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes