Dose Finding Study of Ibrutinib Plus Lenalidomide / Rituximab in Relapsed or Refractory Mantle Cell Lymphoma

Inclusion Criteria: * Age greater than or equal to 18 years. * Histologically or cytologically confirmed diagnosis of MCL. * Relapsed or refractory MCL patients who have received at least one prior therapy are eligible. Patients who have previously received high-dose chemotherapy with peripheral stem cell support are eligible. * Presence of at least one lymph node evaluable or mass measurable for response. * Eastern Cooperative Oncology Group Performance Status greater than 2. * Platelets \> 75,000/μL and absolute neutrophils count (ANC) \> 1,000/μL within 14 days of study registration (unless the treating physician deems the neutropenia is related to bone marrow involvement, then an ANC of \> 750/mm 3 is allowed) * Normal renal function defined as serum creatinine less than 2. * Recovery from any previous treatment therapy. * Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test * All study participants must be registered into the mandatory Revlimid REMS® program, and be willing and able to comply with the requirements of the REMS® program. * Females of reproductive potential must adhere to the scheduled pregnancy testing as required in the Revlimid REMS® program. * Ability to understand, and willingness to sign, a written informed consent document. * Able to take aspirin (81 or 325 mg) daily as prophylactic anti-coagulation (patients intolerant to ASA may use low molecular weight heparin). * Normal organ and bone marrow function parameter: Laboratory tests Required value WBC \>3000/μL\* Absolute neutrophils count \>1,000/μL\* Platelets \>75,000/μL Total bilirubin \< 1.5Within normal institutional limits AST (SGOT) and ALT (SGPT) \<3 x institutional upper limit of normal Creatinine or creatinine clearance \<1.5 within normal institutional limits \>60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal (calculated by Cockcroft-Gault formula) Exclusion Criteria: * Concomitant use of warfarin or other Vit K antagonists * Central nervous system (CNS) involvement by lymphoma at time of enrollment. * Other medical conditions that would potentially interfere with patient participation in this trial. * A second malignancy, other than basal cell carcinoma of the skin or in situ carcinoma of the cervix (unless for other tumor type patient was treated with curative intent at least 2 years previously.) * Known human immunodeficiency virus (HIV-1) infection or chronic hepatitis B, or C (Hep B serology positive without active infection will be eligible) * Active, clinically serious infection \> CTCAE grade 2. Patients may be eligible upon resolution of the infection. * Major surgery or significant traumatic injury within 28 days of the first dose of study drug. * Use of any other standard chemotherapy, radiation therapy, or experimental drug therapy for the treatment of MCL within 21 days of starting treatment or 5 half life times (whatever is shorter) * Patients with grade 3/4 cardiac problems, as defined by the New York Heart Association (NYHA) criteria: * History of uncontrolled or symptomatic angina * History of uncontrolled arrhythmias * Myocardial infarction \< 6 months from study entry * Uncontrolled or symptomatic congestive heart failure * Ejection fraction below the institutional normal limit * Any other cardiac condition that, in the opinion of the treatment physician, would make this protocol unreasonably hazardous for the patient * Patients unwilling or unable to comply with the protocol.