Pilot Trial of Antibiotics Versus Surgery for Treating Acute Appendicitis

Inclusion Criteria: * Adult or child ages ≥5 years; * Diagnosis of acute uncomplicated appendicitis, confirmed by CT, ultrasound and/or MRI performed within 24 hours of consent, as read by an attending radiologist, and confirmed by consultation of an attending surgeon; * Ability to provide written informed consent (and for subjects ages 5-17, consent from their parent/guardian and assent if applicable); and * Negative pregnancy test for subjects who are women of childbearing potential. Exclusion Criteria: * instability/severe sepsis, appendiceal perforation by imaging, serious co-morbidities limiting randomization, pregnancy, and inability to complete the treatment protocol.