Evaluate the Pharmacokinetics of Simvastatin When Coadministered With PEX168 in Healthy Adult Subjects

Inclusion Criteria: An individual who met all of the following criteria was eligible for the study. 1. Healthy male aged 18 to 45 years (including both ends) at the time of signing the informed consent. 2. Weighing not less than 50kg，Body Mass Index (BMI)of 18 to 25kg/m2. 3. No history of cardiovascular, liver, kidney, gastrointestinal, neuropsychiatric and other diseases, no history of drug allergy. 4. Capable of giving written informed consent, which included compliance with the requirements and restrictions listed in the consent form. Exclusion Criteria: 1. Known for any study drug allergy (PEX168, simvastatin) or similar drug allergy (GLP-1 receptor agonists, GLP-1 analogue, statins) or allergic constitution; 2. Having Alcohol and drug abuse within first 6 months before screening; 3. Smoked within 3 months before screening; 4. Received GLP-1 receptor agonists, GLP-1 analogs, DPP-IV inhibitors, or any other similar structure drug for treatment before screening; 5. Following a thorough medical examination, clinically significant abnormalities were found; 6. In screening period, blood pressure greater than 140 / 90mmHg, retest after diagnosis or pulse rate is higher than 100bpm person; 7. In screening period, ECG QTc\> 450ms, diagnosed after retest; 8. In screening period, serum creatinine or urine protein is abnormal, and were determined to be clinically significant by the investigator; 9. In screening period, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ- glutamate GGT (γ-GT), total bilirubin (Tbil) is greater than the normal range limit, and investigator determines to have clinical significance; 10. In screening period, creatine kinase (CK) exceeds the upper limit of the normal range, and judged by the investigator to be clinical significant; 11. In screening period, having thyroid dysfunction; 12. Before screening there is a history of medullary thyroid cancer; 13. Having any surgery (including the impact of gastric emptying of gastrointestinal surgery) within 6 months before screening; 14. Participate in blood donation and donation amount ≥400ml within three months before screening, or who participate in blood donation or blood transfusion within a month; 15. Using any of the tested drugs may affect prescription drugs, nonprescription drugs, herbs, food (such as grapefruit juice) or food supplements persons 2 weeks before screening; 16. Drinking medication or caffeine-containing xanthine food and beverage (listed in annex 3), strenuous exercise, or other effects of drug absorption, distribution, metabolism, excretion and other factors 2 days before screening. 17. Any clinically significant by the investigator determined that acute diseases before Screening occurred within a month too; 18. There is a history of pancreatitis or acute pancreatitis before screening; 19. Having dyslipidemia, coronary heart disease, and a history of high cholesterol before screening. 20. There are lung disease histories, history of chronic liver and gallbladder disease, cholecystitis history, history of bladder disease, a history of colon inflammation before screening. 21. Within three months before screening participated in any drug or medical device clinical trials were (including placebo); 22. Hepatitis B surface antigen, hepatitis C antibody, HIV antibody, syphilis antibody test positive; 23. Reluctant to take effective contraceptive methods of contraception. During the trial, there was family planning within six months after their spouses during the trial or the last dose (first 33 days); 24. The investigator believe that any situation that might lead to any subject cannot be completed or to the subject of this study bring significant risk.