Bioimpedance Analysis Guided Volume Expansion for the Prevention of Contrast Induced-acute Kidney Injury

Mahidol University56 enrolled

Overview

Bioelectrical impedance analysis guided volume expansion for the prevention of contrast induced-acute kidney injury

Compared bioelectrical impedance analysis guided hydration therapy versus standard hydration for the prevention of contrast induced-acute kidney injury

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

X-ray Contrast Media Adverse Reaction

Interventions

Bioimpedance guidedOTHER

bioelectrical impedance analysis guided hydration therapy : 7.5% Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV in 6 hours rate was adjusted regarding to extracellular water/total body water * extracellular water/total body water \< 0.36 : 4 ml/kg/hr * extracellular water/total body water 0.36-0.4 : 2 ml/kg/hr * extracellular water/total body water \> 0.4 : 1 ml/kg/hr

standard hydrationOTHER

standard hydration : 7.5%Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV 1 ml/kg/hr in 6 hours

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-90 yr 2. Chronic kidney disease stage 3 \& 4 (eGFR 15-60 ml/min/m2) 3. elective cardiac catheterization Exclusion Criteria: 1. Contrast media administration in the past 14 days 2. congestive heart failure (NYHA III-IV, ascites , pleuropericardial effusion ,severe valvular heart disease 3. Kidney transplant status or RRT 4. Emergency cardiac catheterization 5. Allergy to radiographic contrast media 6. Unstable renal function (change in serum creatinine ≥ 0.5 mg/dl or 25% within 14 days prior to the study 7. Not inform consent 8. left ventricular ejection fraction \< 40 % 9. Liver cirrhosis child B or C 10. Dosage of angiotensin-converting enzyme inhibitor /angiotensin II receptor blocker changed in past 2 wk

Outcomes

Primary Outcomes

serum creatinine at 48-72 hours after contrast administration

Acute kidney injury

Time frame: 48-72 hr

Secondary Outcomes

serum creatinine at 2 weeks after contrast administration

Renal replacement therapy

Time frame: 2 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.