The patients with severe hypernatremia who received conventional treatment are often undertreated. Continuous venovenous hemofiltration (CVVH) can effectively remove solute or water from circulation system. Several case reports demonstrated that CVVH could effectively decrease serum sodium concentration of the patients with severe hypernatremia. The use of CVVH for acute severe hypernatremia in critically ill patients could improve patient survival by effectively decreasing the serum sodium concentration to a normal level.
Date collection: 1. Demographic (gender, age, race, weight, history of drug allergy, complicating diseases, drug combination and combination therapy) 2. CVVH treatment (time, blood vessel, blood flow, replacement fluid flow, the type and dose of anticoagulant, limited to the test group) 3. Vital signs (blood pressure, heart rate, respiratory frequency, body temperature) 4. Severity of disease 5. General treatment (Vasoactive drugs, mechanical ventilation, diuretic, steroid hormones) 6.24 hours input 7.24 hour output 8.Daily sodium intake 9.Adverse events were confirmed 10.Laboratory date: Routine blood test Blood biochemical Blood gas analysis Blood electrolyte Plasma osmotic pressure Urine osmotic pressure Plasma osmotic pressure Urinary electrolyte excretion fraction
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
If the serum sodium concentration \>150mmol/L, When filter occurred clotting, replace the filter to CVVH treatment
If the serum sodium concentration ≤150mmol/L, When filter occurred clotting, as the end of treatment.
Xijing Hospital of Nephrology
Xi'an, Shaanxi, China
RECRUITING7-day all cause mortality
Time frame: 7days
Glasgow Coma score changes
On the third day of the Glasgow Coma score minus baseline of the Glasgow Coma score
Time frame: 3 days
Sequential Organ Failure Assessment score changes
On the third day of the Sequential Organ Failure Assessment score minus baseline of the Sequential Organ Failure Assessment score
Time frame: 3 days
Acute Physiology and Chronic Health Evaluation II score changes
On the third day of the Acute Physiology and Chronic Health Evaluation II score minus baseline of the Acute Physiology and Chronic Health Evaluation II score
Time frame: 3 days
The average reduce rate of serum sodium
The average reduce rate of serum sodium was calculated as following: (serum sodium concentration before treatment (mmol/L) - serum sodium concentration after treatment (mmol/L)) / time after treatment (hours)
Time frame: 3 days
24-hour correction of hypernatremia
Twenty-four-hour correction of hypernatremia was defined as the reduction of serum sodium concentration to ≤145 mmol/L within 24 hours after the start of treatment.
Time frame: 24-hour
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.