Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty

University of Chile63 enrolled

Overview

Lipoabdominoplasty and liposuction are one of the most common plastic surgeries. The management of postoperative pain is complex. Non Steroidal Anti Inflammatory Drugs (NSAIDs) are insufficient, while opioids are avoided by their adverse effects and regional techniques are hampered by a premature discharge. In this context, the investigators seek an intraoperative multimodal analgesic technique blocking NMDA receptors with ketamine plus magnesium to significantly decrease postoperative pain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Pain, Postoperative

Interventions

SalineDRUG

50 mL syringe will be infused at 0.3 mL/Kg in bolus and then 0.15 mL/Kg/h 100 mL flask will be infused at 1mL/Kg in bolus for 30 min and then 0.25mL/Kg/h

KetamineDRUG

50 mL syringe will be infused at 0.3 mL/Kg in bolus and then 0.15 mL/Kg/h 100 mL flask will be infused at 1mL/Kg in bolus for 30 min and then 0.25mL/Kg/h

Ketamine + magnesiumDRUG

50 mL syringe will be infused at 0.3 mL/Kg in bolus and then 0.15 mL/Kg/h 100 mL flask will be infused at 1mL/Kg in bolus for 30 min and then 0.25mL/Kg/h

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female and male * 18 years or older * Liposuction and lipoabdominoplasty * ASA 1 and 2 * BMI 21-28 Kg/m2 * Full secondary education Exclusion Criteria: * Patients with surgeries added to the main proceedings * Scheduled to tuck in Flor de Lis or Body Lift * History of use of analgesic drugs 48 hours before surgery * Peripheral central neurological diseases * Known allergy will be excluded to medication in use in this study (ketamine, magnesium, clindamycin and penicillin or other)

Locations (1)

Hospital Clinico de la Universidad de Chile

Santiago, RM, Chile

Outcomes

Primary Outcomes

Opioids consumption

Time frame: 12 h after surgery

Postoperative Pain (Postoperative Pain and Disability Scale)

Postoperative Pain and Disability Scale (Body-PPDS) will be used to quantify pain

Time frame: 2, 7, 14, 21, 45 and 90 days after surgery

Secondary Outcomes

Early postoperative pain (Visual analogue pain scale)

Visual analogue pain scale (0-10) will be used to quantify pain

Time frame: 0, 2, 4, 6, 12 and 24 h after surgery

Early postoperative pain (Time to first request for supplemental analgesia)

Time to first request for supplemental analgesia.

Time frame: 1 day

Disability (Time delay in returning to work)

Time delay in returning to work.

Time frame: 90 days

Postoperative Chronic Pain (McGill scale)

McGill scale for chronic painwill be used to quantify pain

Time frame: Day after surgery, 7, 30 and 90 days after surgery

Data from ClinicalTrials.gov

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