Scintigraphic Comparison of Lung Deposition With Two Nebulizers During Invasive Mechanical Ventilation

Cliniques universitaires Saint-Luc- Université Catholique de Louvain20 enrolled

Overview

Many devices are available for nebulising drug solution during invasive mechanical ventilation. Vibrating-mesh nebulizers ensure the highest lung deposition output. A recent international survey on aerosol therapy during mechanical ventilation (Ehrmann et al. 2013) reported that jet nebulizers remained the mostly used. The aim of this study is to compare lung deposition of a radiolabeled administered with both nebulizers during invasive mechanical ventilation by planar scintigraphy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Post-operative Neurosurgery

Interventions

technetium-99m - Diethylenetriaminepentaacetic acid

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Invasive mechanical ventilation * Healthy lungs Exclusion Criteria: * Discontinued procedure due to adverse events.

Locations (1)

Cliniques Universitaires Saint-Luc

Brussels, Belgium

Outcomes

Primary Outcomes

Pulmonary deposition

Time frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes

Secondary Outcomes

Penetration index

Time frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes

Mechanical ventilation settings

Time frame: During nebulisation time, an expected average of 15 minutes

Lung function

Time frame: Preoperative assessment, the day before inclusion

Data from ClinicalTrials.gov

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