Prevention of Severe Postpartum Hypertension

Indiana University

Overview

The purpose of this study is to determine whether postpartum administration of furosemide to women with antepartum hypertensive disorders (gestational hypertension, preeclampsia) or elevated blood pressure in the first 24 hours following delivery reduces severe postpartum hypertension.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Conditions

Hypertension

Interventions

FurosemideDRUG

40 mg furosemide on postpartum day 1-6

Potassium chlorideDRUG

20 meq potassium chloride on postpartum day 1-6

Placebo #1DRUG

Placebo (for furosemide)

Placebo #2

Eligibility

Sex: FEMALEHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Women \> 18 years of age or emancipated minors Women undergoing vaginal or cesarean delivery at \> 23 weeks gestation with: * Antepartum diagnosis of gestational hypertension * Antepartum diagnosis of preeclampsia * Antepartum diagnosis of preeclampsia with severe features * Mild hypertension (\<150/100) in first 24 hours following delivery Exclusion Criteria: * Chronic hypertension * Allergy to furosemide * Pre-existing hypokalemia (serum K \< 3.0 meq/L) * Chronic kidney disease * Serum Cr \> 1.1 * Inability to obtain informed consent * Pre-existing diuretic use * Oliguria

Locations (2)

Indiana University School of Medicine

Indianapolis, Indiana, United States

Washington University School of Medicine

St Louis, Missouri, United States

Outcomes

Primary Outcomes

Composite maternal morbidity

Requiring antihypertensive medication at discharge, readmission for blood pressure, end-organ damage from hypertension