Evaluation the Pharmacokinetics, Safety, Tolerability of BCD-021 in Patients With Neovascular Age-related Macular Degeneration

Inclusion Criteria: * subject has provided informed consent; * men and women; * patients must be from 50 years old; * wet AMD in the study eye, defined as active choroidal neovascular membrane (CNV) (not previously treated with intravitreal injection of an anti-VEGF drug), including retinal angiomatous proliferation (RAP), with oedema involving the fovea as demonstrated with optical coherence tomography (OCT); * best corrected VA for the studied eye ranging between 20/32 (6.3/10) and 20/320 (0.6/10) with ETDRS scale; * size of lesion \< 12 disk area; * in case of occult neovessels, proof required of recent development of the lesion: loss of VA of at least 5 letters ETDRS in the last 3 months OR appearance of a subretinal hemorrhage OR increase in the size of the lesion (\> 10%) using fluorescein angiography during the last month by comparison with the last 3 months OR appearance of OCT criteria of macular oedema type, serous separation of neuro-epithelium, separation of the pigmented epithelial during the last month before inclusion to trial; * only one eye of each study patient may be recruited into the study; * patient's ability to follow the protocol procedures; * male and female patients with normal reproductive function and their sexual partners are aware and willing to use voluntarily reliable methods of contraception during the whole period of the study including the screening period. Exclusion Criteria: * Previous or current treatment with intravitreal injection of an anti-VEGF drug (ranibizumab, bevacizumab, aflibercept or pegaptanib, etc.); * Other healing treatment in the studied eye during the last 3 months before the first injection; * Former vitrectomy in the study eye; * Medical history of photocoagulation in the studied eye; * Involvement in another clinical study (studied eye and/or the other eye); * Subretinal hemorrhage reaching the fovea centre, with a size \> 50% of the lesion area; * Fibrosis or retrofoveal retinal atrophy in the studied eye; * Retinal pigment epithelial tear reaching the macula in the studied eye; * Choroidal neovascularisation not related to a AMD in the studied eye; * Medical history of intravitreal medical device in the studied eye; * Active or suspected ocular or peri-ocular infection; * Acute conjunctivitis, keratitis, scleritis, or endophthalmitis; * Serious active intra-ocular inflammation in the studied eye; * Macula-foramen of the studied eye; * Myopia larger than -8 diopter; * Former corneal grafting of the studied eye; * Medical history of auto-immune or idiopathic uveitis; * Proved diabetic retinopathy; * Intra-ocular pressure ≥ 25 mmHg despite two topical hypotonic treatments; * Medical history of intra-ocular surgery within 2 months before the first injection in the studied eye; * Aphakia or lack of lens capsule (not removed by laser) in the studied eye; * Any illness or ocular condition that would require an intra-ocular surgery in the studied eye within 12 months after the inclusion; * Known hypersensitivity to bevacizumab or another drug composite of the medicinal products used; allergy to anaesthetic eye drops; * Arterial hypertension that is not controlled by an appropriate treatment; * Previous or current treatment with systemic administration of bevacizumab; * Pregnancy and breast-feeding; * Any determined immunodeficiency; * Syphilis, HIV, hepatitis B, any history of hepatitis C virus; * Any mental disorder that can create a risk for the patient or influence the patient's ability to follow the study protocol; * Drug addiction, alcoholism. * Presence or history of malignant neoplasm (including lymphoproliferative disease); * Simultaneous participation in any other clinical trial.