Acclimatization of Healthy Subjects During a Stay at 3200 m

University of Zurich20 enrolled

Overview

The study evaluates respiratory acclimatization in healthy lowlanders staying for 3 weeks at 3200 m.

This study evaluates the effect of 3 weeks altitude acclimatization on sleep related breathing disturbances in healthy subjects staying at 3200 m. Participants living in Bishkek, Kyrgyzstan (700 m), will be transferred by car within 4 h to the Tuja Ashu high altitude clinic (3200 m). Outcomes will be assessed repeatedly during the stay at 3200 m.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Effects of High Altitude

Interventions

Altitude exposureOTHER

Participants will stay for 3 weeks at an altitude of 3200 m

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Perfect health * Born, raised and currently living at low altitude (\<800m) * Informed consent. Exclusion Criteria: * Any acute or chronic disease * heavy smoking (\>20 cigarettes per day).

Locations (1)

National Center of Cardiology and Internal Medicine

Bishkek, Kyrgyzstan

Outcomes

Primary Outcomes

Mean nocturnal oxygen saturation measured by pulse oximetry

Difference in mean nocturnal oxygen saturation between night 1 and night 7

Time frame: night 7 at 3200 m

Secondary Outcomes

Mean nocturnal oxygen saturation measured by pulse oximetry

Difference in mean nocturnal oxygen saturation between night 1 at 3200 and night 1 at 700 m

Time frame: night 1 at 3200 m

Mean nocturnal oxygen saturation measured by pulse oximetry

Difference in mean nocturnal oxygen saturation between night 21 and night 1 at 3200 m

Time frame: night 21 at 3200 m

Mean nocturnal oxygen saturation measured by pulse oximetry

Mean nocturnal oxygen saturation during night 1 at 700 m

Time frame: night 1 at 700 m (low altitude baseline)

Data from ClinicalTrials.gov

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