Associations Analysis Between Lifestyle and Osteoporosis

Shanghai Tongji Hospital, Tongji University School of Medicine3,100 enrolled

Overview

A large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the Chinese population by using self-reported questionnaire methods. More than 3000 participants were recruited in communities in Shanghai. Data involved in demographic information, lifestyle, dietary habits, medical history and clinical biomarkers were collected. Every participants were measured bone mineral density (BMD g/cm2) at calcaneus by standardized quantitative ultrasound (QUS, Hologic Inc., Bedford, MA, USA) utilizing T-scores based on WHO criteria. A standard statistical analysis including univariate and multiple variables regression analysis to explore the risk or preventive factors involved in Chinese lifestyle associated with osteoporosis.

Study Type

OBSERVATIONAL

Enrollment

3,100

Conditions

Osteoporosis of Disuse With Current Pathological Fracture

Interventions

OTHER

This is a cross-sectional study, and we do not assign specific interventions to the subjects of the study.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participants aged 30-90 years were recruited from rural and urban communities in Shanghai. Exclusion Criteria: * Some participants with chronic diseases and conditions that might potentially affect bone mass, structure, or metabolism were excluded. Briefly, the exclusion criteria were as follows: a history of 1. serious residual effects of cerebral vascular disease; 2. serious chronic renal disease (Glomerular filtration rate - GFR \< 30 mL/min/1.73m2); 3. serious chronic liver disease or alcoholism; 4. significant chronic lung disease; 5. corticosteroid therapy at pharmacologic levels; 6. evidence of other metabolic or inherited bone disease, such as hyper- or hypoparathyroidism, Paget disease, osteomalacia, or osteogenesis imperfecta; 7. recent (within the past year) major gastrointestinal disease, such as peptic ulcer, malabsorption, chronic ulcerative colitis, regional enteritis, or significant chronic diarrhea; 8. Cushing syndrome; 9. hyperthyroidism; and 10. any neurologic or musculoskeletal condition that would be a non-genetic cause of low bone mass.

Locations (2)

Huasha Hospital

Shanghai, Shanghai Municipality, China

Huashan Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

osteoporosis accessed by Bone Mass Density (BMD)

The bone mineral density (BMD g/cm2) was measured at calcaneus by standardized quantitative ultrasound (QUS, Hologic Inc., Bedford, MA, USA) utilizing T-scores based on WHO criteria, which were obtained from the automated equipment. T-score refers to the ratio between patient's BMD and that of young adult population of same sex and ethnicity. T-score of \> -1 was taken as normal, between -1 and -2.5 osteopenic and \< -2.5 as osteoporotic.

Time frame: participants will be measured for the duration of outpatient stay, an expected average of 2 weeks

Data from ClinicalTrials.gov

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