Phase 1 Study of CM082 in Patients With wAMD

Inclusion Criteria: * Active choroidal neovascularization (CNV) associated with AMD, as evidenced on fluorescein angiography (FA) and OCT. * Patients with either no previous anti-VEGF therapy or prior anti-VEGF therapy with evidence of response to treatment and the need for additional treatment. * Early Treatment Diabetic Retinopathy Study (ETDRS) BCVA 20/40 to 20/320 in the study eye(s). * Adequate bone marrow, hepatic, and renal functions. * Willing and able to provide written informed consent, comply with the investigational study protocol and return for all study visits. Exclusion Criteria: * Patients with Polypoidal Choroidal Vasculopathy (PCV) as evidenced on Indocyanine Green Angiography (ICG). * Previous treatment with photodynamic therapy (PDT), external beam radiation, subfoveal focal laser photocoagulation, submacular surgery, or transpupillary thermotherapy. * CNV due to causes other than AMD, including ocular histoplasmosis syndrome, angioid streaks, multifocal choroiditis, choroidal rupture, or pathologic myopia. * Geographic atrophy involving the foveal center in the study eye. * Any retinal vascular disease or retinal degeneration other than AMD in the study eye. * Any significant disease in the study eye that could compromise best-corrected visual acuity. * Cataract surgery in the study eye within three months of screening. * Trabeculectomy or aqueous shunt or valve in the study eye. * Use of any investigational agent or participation in any other clinical trial of an investigational agent or investigational therapy within thirty (30) days of baseline. * Females of child bearing potential that are pregnant or not using medically acceptable contraception; males unwilling to take adequate contraceptive measures. * Serious allergy to or prior significant adverse reaction to fluorescein. * Undiagnosed acute illness first observed during screening or between screening and baseline, or severe concurrent medical conditions that, in the investigators judgment, represent a safety concern. * Severe cardiac disease, symptomatic congestive heart failure, unstable angina, acute coronary syndrome, myocardial infarction or coronary artery revascularization, or arterial thrombosis within 12 months of start of study drug, inadequately controlled hypertension, or ventricular tachyarrhythmias requiring ongoing treatment. * QTc ≥450 msec or subjects with a history of risk factors for Torsades de Pointes. * Stroke or transient ischemic attack within 12 months of trial entry. * Clinically significant impaired renal or hepatic function. * Presence of active gastrointestinal (GI) disease or other condition that will interfere significantly with the absorption, distribution, metabolism, or excretion of CM082. * Serious active infection, other serious medical condition or any other condition that would impair the ability of the subject to administer the investigational drug or to adhere to the study protocol requirements. * Presence of any condition which, in the judgment of the investigator, would prevent the subject from completing the study. * Need to take any medicine that is a strong inhibitor or inducer of CYP3A4.