Research has shown that reducing the time spent sitting can reduce the risk of many diseases, such as diabetes and heart disease, and improve health. It is estimated that many older adults typically spend 70% of their waking day sitting, but little is known about whether reducing sitting promotes health and well-being in this age group. The aim of this research is to investigate the health effects of reducing sitting time by replacing it with short periods of standing or walking in adults over the age of 65.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
76
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Avenue
Glasgow, United Kingdom
Leicester Diabetes Centre, Diabetes Research Unit, University of Leicester, Leicester General Hospital
Leicester, United Kingdom
Insulin area under the curve
Samples will be batched and analysed at the end of the study within a certified research laboratory at the Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow. Samples collected at the Leicester Diabetes Centre will be sent by courier in specialist containers and packed with dry ice.
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Glucose area under the curve
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Triglyceride area under the curve
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
1H NMR Metabolomics spectroscopy
Hydrogen-1 Nuclear Magnetic Resonance assessment undertaken on blood samples collected throughout experimental intervention days
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Blood pressure
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Felt Arousal Scale (0-5)
Positive affect and mood measured using the 6-point Likert Felt Arousal scale (0 = "low arousal" to 5 = "high arousal") that will be used to assess arousal.
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Feeling Scale (-5 to +5)
Positive affect and mood measured using the 11-point Likert Feeling Scale (-5 = "very bad" to +5 = "very good") will be used to assess affective valence.
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Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Semantic Verbal Fluency Test (number of items)
The Semantic Verbal Fluency Test assesses semantic memory and language, and participants will be asked to name as many items as they can that belong to a particular category. The categories selected for each of the experimental days will be clothing and animals.
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Hopkins Verbal Learning Test (number of words recalled)
The Hopkins Verbal Learning Test assesses verbal learning and working memory and requires immediate and delayed recall of a series of 12 words over three learning trials. Participants will be requested to undertake the delayed recall component at the end of the first set of cognitive function tests and during the second set of cognitive function tests on experimental intervention days.
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Trail Making Tests A (time to complete)
The Trail Making Tests A assesses cognitive flexibility and requires connecting randomly located numbers in numerical order (e.g. 1,2,3,4).
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Trail Making Tests B (time to complete)
The Trail Making Tests B assesses cognitive flexibility and requires connecting randomly located numbers and letters in numerical and alphabetical order alternately (e.g. 1,A,2,B,3,C).
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Rapid Visual Information Processing Test (number of sequences detected and errors)
The Rapid Visual Information Processing Test assesses sustained visual attention using numbers and requires both selective attention and working memory. This test displays a number on screen that changes between odd and even digits and individuals must detect target sequences of three odd or three even consecutive digits.
Time frame: 3 experimental intervention study visits over an estimated period of 1 month
Karolinska Sleepiness Scale (1-9)
Sleep quality measured using the 9-point Likert Karolinska Sleepiness Scale (1= "very alert" to 9= "very sleepy, fighting sleep, an effort to keep awake") based on a self-reported subjective assessment of the participant's level of drowsiness at the time.
Time frame: 3 experimental intervention study visits over an estimated period of 1 month