Stimulant Effects on Brain Activity

Inclusion Criteria * Healthy, non-smoking, male and female volunteers, between 18 to 35 years of age inclusive, right-handed * Body Mass Index that is within 18.5-29.9 kg/m2, inclusive * Healthy, according to the medical history, vital signs, and physical examination (within 2 years prior to study enrollment) * Systolic blood pressure between 100-140 mmHg, inclusive, and diastolic blood pressure between 60-90 mmHg, inclusive, and heart rate between 50-100 bpm, inclusive, unless deemed not clinically significant by the Principal Investigator/ Sub-Investigator? * Capable of giving written informed consent prior to receiving any study medication * Female subjects must fulfill at least one of the following: * Agree to avoid pregnancy and use medically acceptable method of contraception from at least 30 days prior to the study, during the study, and until 30 days after the study has ended (last study procedure). Medically acceptable methods of contraception include oral contraceptives, hormonal patch, implant or injection intrauterine device, or double barrier method (condom with foam or vaginal spermicidal suppository, diaphragm with spermicide). Complete abstinence alone can be used as a method of contraception. * Be surgically sterile for a minimum of 6 months * Post-menopausal for a minimum of 1 year Exclusion Criteria * Known history or presence of any clinically significant hepatic (e.g. hepatic necrosis, jaundice, hepatobiliary disease), renal, gastrointestinal (e.g. peptic ulcer), cardiovascular (e.g. angina, myocardial infarction), cerebrovascular, pulmonary, endocrine (e.g. diabetes, hypophosphatemia), immunological, musculoskeletal (e.g. rhabdomyolysis, myopathy), neurological, psychiatric, dermatological, or hematological disease or condition * Presence of any clinically significant illness within 30 days prior to dosing * Presence of any significant physical or organ abnormality * Known history or presence of: * Alcohol abuse or dependence within one year prior to drug administration * Drug abuse or dependence * Hypersensitivity to methylphenidate or other medications * Gout * Food allergies and/or presence of any dietary restrictions * Severe allergic reactions (e.g. anaphylactic reactions, angioedema) * Participation in another clinical trial or receiving an investigational drug within 30 days of the study commencement or during the study * Use of any prescription medication within 14 days prior to drug administration (except for hormonal contraceptives) * Use of any over-the-counter medications (including herbal and/or dietary supplements and/or teas) within 14 days prior to drug administration (except for spermicidal/barrier contraceptive products) * Any major surgery within 6 months prior to the start of the study * Pregnant or lactating * Lactose intolerance * Contraindication for MRI (using hospital's standard screening procedure) * Smoking