Traditional Chinese Medicine as Preventive Method for Osteoporosis Induced by Adjuvant Endocrine Therapy

Inclusion Criteria: * Histologically confirmed invasive breast cancer; * Post-surgery, primary lesion been removed; * Post-Menopausal patients or pre-menopausal patients who will receive ovarian function suppression; * Histologically confirmed ER and/or PR positive ; * Receiving adjuvant AIs therapy in the following one years; * Leukocyte ≥ 3\*10(9)/L; Platelets ≥ 75\*10(9)/L; * Serum glutamate oxaloacetate(AST/SGOT) or serum glutamic-pyruvic transaminase(ALT/SGPT) \<2.5 times of upper limit of normal range; * Serum creatinine/blood urea nitrogen(BUN) ≤ upper limit of normal (UNL) range; * Written informed consent according to the local ethics committee equirements; Exclusion Criteria: * Metastatic Breast Cancer; * Received Neo-Adjuvant Endocrine Therapy; * History of pelvic fracture or bone metabolic disease; * Received drugs interfering bone metabolism in the last 12 months; * Baseline Bone Mineral Density: T \< -2SD; * With other primary malignant disease; * With severe non-malignant co-morbidity that will influence long-term follow up; * Known severe hypersensitivity to any drugs in this study;