Altered PSA Test Due to Possible Suspected Heterophilic Antibodies

University of Zurich50 enrolled

Overview

The purpose of this study is to investigate if clinically non explainable high or low Prostate-specific antigen (PSA) levels are associated with heterophilic antibodies in the serum of participants. The investigators will examine if heterophilic antibodies are the reasons of altered PSA levels.

Study Type

OBSERVATIONAL

Enrollment

Conditions

PSA

Eligibility

Sex: MALEMin age: 40 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male, with a a clinically high or low unexplainable PSA measurement * Age between 40 and 90 years * Written informed consent Exclusion Criteria: * Female * No PSA measurement available or planned * Age over 90 or under 40 years

Locations (1)

University Hospital Zürich

Zurich, Switzerland

Outcomes

Primary Outcomes

Presence of heterophilic antibodies in the serum of participants

Heterophilic antibodies will be measured in the Blood serum of participants by sandwich Elisa assay

Time frame: 1.5 years

Altered PSA levels due to the Presence of Heterophilic antibodies

If heterophilic antibodies were present in the serum of the participant, another PSA test will be ran after absorbance of heterophilic antibodies to investigate whether PSA levels are changed without the presence of heterophilic antibodies

Time frame: 1.5 years

Data from ClinicalTrials.gov

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