Xenogenous Collagen Matrix Graft With or Without Enamel Matrix Proteins Derivative for Root Coverage

University of Campinas, Brazil49 enrolled

Overview

The purpose of this study is to evaluate the reduction of gingival recession of single Miller Class I and II defects treated by coronally advanced flap with subepithelial porcine collagen matrix graft and / or enamel matrix proteins.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Gingival Recession

Interventions

MucograftDEVICE

Coronally advanced flap associated to Xenogenous collagen matrix graft (mucograft) for the treatment of gingival recessions Miller Class I or II.

EmdogainDEVICE

Coronally advanced flap associated to Enamel Matrix Derivative (Emdogain) for the treatment of gingival recessions Miller Class I or II.

Coronally Advanced flapPROCEDURE

Coronally advanced flap for the treatment of gingival recessions Miller Class I or II.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years. * Presence of at least one Class I or II Miller gingival recession ≥ 2.5 mm in maxillary canines or premolars with identifiable cementum-enamel junction (CEJ) and without deep non-carious cervical lesions (\< 0.5 mm): A +(Pini-Prato et al. 2010). * Aesthetic complaint and/or presence of dentin hypersensitivity to air stimulus. * Full-mouth visible plaque index ≤ 20% (Ainamo \& Bay 1975). * Full-mouth sulcus bleeding index ≤ 20% (Mühlemann \& Son 1971). Exclusion Criteria: * Smoking. * Pregnancy. * Presence of systemic disorders (diabetes, hypertension, heart disease or any other condition that could contraindicate periodontal surgery). * Use of medications (immunosuppressants, phenytoin or anything else that might affect mucosal healing and repair). * Previous periodontal surgery in the area.

Locations (1)

Piracicaba Dental School, State University of Campinas

Piracicaba, São Paulo, Brazil

Outcomes

Primary Outcomes

Recession Reduction

Measured as a difference between gingival margin between gingival recession depth at baseline and gingival recession at 6 months follow-up.

Time frame: 6 months

Secondary Outcomes

Complete root coverage

Assessed as percentage of sites with complete root coverage

Time frame: 6 months

Data from ClinicalTrials.gov

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