The purpose of this study is to compare the efficacy of in vitro fertilization (IVF) versus laparoscopic ovarian drilling (LOD) in infertile women having clomiphene citrate (CC) resistant polycystic ovarian syndrome (PCOS).
Women will be randomly divided into two groups; IVF group and LOD group. Women in the IVF group will undergo one full IVF cycle. Women in the LOD group will be subjected to LOD followed by ovarian stimulation if spontaneous ovulation does not occur within 2 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Fertility Care Unit (FCU) in Mansoura University Hospital
Al Mansurah, Dakahlia Governorate, Egypt
Private fertility care centers
Al Mansurah, Dakahlia Governorate, Egypt
Live birth rate
Number of live births divided by the number of women
Time frame: 9 months
Clinical pregnancy rate
Number of clinical pregnancies divided by the number of women
Time frame: 6-8 weeks gestational age
Multifetal pregnancy rate
Number of multifetal pregnancies divided by the number of clinical pregnancies
Time frame: 12 weeks gestational age
Miscarriage rate
Number of first trimester miscarriages (before 12 weeks gestational age) divided by the number of clinical pregnancies
Time frame: 12 weeks gestational age
Incidence of early ovarian hyperstimulation syndrome (OHSS)
Incidence of OHSS within 9 days of final triggering of oocyte maturation
Time frame: Within 9 days of final triggering of oocyte maturation
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