The standard CXL technique involves removal of the epithelium to enable riboflavin to penetrate into stromal tissue, to avoid epithelial debridement and increasing the patient's comfort and safety transepithelial corneal crosslinking (CXL) was suggested. Iontophoresis of riboflavin is one of approach for riboflavin impregnation. In this study, the investigators compared the results of standard corneal crosslinking (CXL) and transepithelial CXL via iontophoresis of riboflavin after 24 months follow up.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
126
Standard surface UVA irradiation (370 nm, 3 mW/cm2; UFalink, Russian Federation) was then applied at a 5-cm distance for 30 minutes. During UVA exposure, hypotonic riboflavin drops were continued every 2 minutes.
Kmax, D
Using topography measurements, clinical stabilisation is defined as an increase of no more than 1 diopter of the maximum keratometry value over the preoperative maximum keratometry value
Time frame: 2 years
Corneal thickness, μm, as measured by OCT tomography
Using optical coherence tomography to estimate the pachymetry changes
Time frame: 2 years
Visual acuity as assessed by Decimal system
Decimal visual acuity assessed on a study later was converted to the logarithm of minimal angle of resolution (logMAR).
Time frame: 2 years
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Device for providing iontophoresis procedure
Riboflavin 0,1% + Dextran T-500
device for UVA irradiation - providing UVA light - 370 nm, 3 mW/cm2