The Safety and Immunogenicity of the DNA-GTU Vaccine Administered to HIV-infected Patients on ART vs Placebo

Inclusion Criteria: 1. Male or female 2. Aged between 18 and 45 years on the day of screening 3. BMI between 19-30 4. Available for follow-up for the duration of the study 5. Willing and able to give written informed consent 6. HIV-1 Clade B infection documented by confirmed antibody test 7. Confirmed on 2 separate occasions in the 6 month period prior to enrolment to have viral load \< 200 copies HIV RNA/ml whilst on ART 8. Nadir CD4+ \> 250 CD4 lymphocytes AND screening CD4 \>200 CD4 lymphocytes 9. Willing to avoid UV tanning or strong sun exposure during the immunisation period of the study 10. Willing to avoid all other vaccines within four weeks of scheduled study vaccinations 11. If heterosexually active female, using an effective method of contraception with partner (combined oral contraceptive pill; injectable or implanted contraceptive; consistent record with condoms if using these; physiological or anatomical sterility (in self or partner) from 14 days prior to the first vaccination until 4 months after the last, and willing to undergo urine pregnancy tests prior to each vaccination 12. If heterosexually active male, using an effective method of contraception with their partner from the first day of vaccination until 4 months after the last vaccination Exclusion Criteria: 1. Pregnant or lactating 2. Use of regular topical treatment on the injection or application site within the last four weeks 3. UV tanning sessions or strong sun exposure within four weeks prior to enrolment 4. Excessive terminal hair growth on the investigational skin areas (to be assessed by reference to a photograph which will be available during screening visit) 5. Individuals in which a skin-fold measurement (cutaneous and subcutaneous tissue) of the upper right or left thigh exceeds 40 mm 6. Clinically relevant abnormality on history or examination including * history of grand-mal epilepsy, seizure disorder or any history of prior seizure * history of syncope or fainting episodes within 1 year of study entry * liver disease including active hepatitis B (surface antigen positive) or C (PCR positive) * any skin condition which may interfere with the trial assessment of the injection site * haematological, metabolic, gastrointestinal (excluding gastritis) or cardio-pulmonary disorders (excluding mild asthma) * a clinically significant abnormality on the ECG * autoimmune disease, or use of regular, systemic immunosuppressives in preceding 3 months 7. Known hypersensitivity to any component of the vaccine formulations used in this trial, or have severe or multiple allergies to drugs or pharmaceutical agents 8. History of severe local or general reaction to vaccination defined as 1. local: extensive, indurated redness and swelling involving most of the antero-lateral thigh or the major circumference of the arm, not resolving within 72 hours 2. general: fever \>= 39.5oC within 48 hours; anaphylaxis; bronchospasm; laryngeal oedema; collapse; convulsions or encephalopathy within 72 hours 9. Receipt of live attenuated vaccine within 60 days of enrolment and any vaccine within 30 days of enrolment. 10. Receipt of an experimental vaccine containing HIV antigens at any time in the past 11. Receipt of immunoglobin within 4 months of screening 12. Participation in another trial of a medicinal product, completed less than 30 days prior to enrolment 13. Grade 2 or above routine laboratory parameters. Hyperbilirubinaemia to be considered an exclusion criterion only when confirmed to be conjugated bilirubinaemia 14. Current use of any electronic stimulation device, such as cardiac demand pacemakers, automatic implantable cardiac defibrillator, nerve stimulators, or deep brain stimulators. 15. Presence of any surgical or traumatic metal implants at the sites of administration 16. Unable to read and speak English to a fluency level adequate for the full comprehension of procedures required in participation and consent. 17. Unlikely to comply with protocol.