Comparison of Anesthetic Efficacy of Bilateral and Unillateral Application of Kovacaine Mist in Healthy Volunteers

Inclusion Criteria: * Male or female 18 years of age or older. * Eight representative maxillary teeth \[(3 (or 2), 4 (or 5), 6, 8, 9, 11, 13 (or 12), and 14 (or15)\] free of observable decay (or other pathology), crowns or veneers, all of which have EPT values of 10-50 at screening. * Normal lip, nose, eyelid, palate, and cheek sensation. * Patency of both left and right nasal airways. * Ability to understand and willingness to sign the study informed consent form, communicate with study investigators, and understand and comply with the requirements of the study protocol. Exclusion Criteria: * Poorly controlled hypertension (blood pressure greater than 150/90 mmHg) or history of coronary heart disease. * Diabetes mellitus. * Any active thyroid disease other than S/P thyroidectomy on thyroid hormone replacement with TSH values in the normal range. * History or presence of narrow-angle glaucoma. * Prostatic enlargement. * History of sinus/nasal surgery that, in the opinion of the investigator, could confound study results. * History of frequent nose bleeds. * Receipt of dental care requiring a local anesthetic within the last 24 hours. * History of allergy to or intolerance of tetracaine, benzyl alcohol, benzocaine, other ester local anesthetics, succinylcholine, or para-aminobenzoic acid (as found in PABA-containing sunscreens). * History of allergy or hypersensitivity to articaine, oxymetazoline, epinephrine, or sulfite antioxidants. * History of drug abuse. * Use of a monoamine oxidase inhibitor within the 3 weeks immediately prior to anticipated study participation. * Nursing, pregnant, suspected of being pregnant, or trying to become pregnant. (Females will be required to undergo pregnancy testing to rule out pregnancy) * Use of any investigational drug and/or participation in a clinical research trial within 30 days of the first study dosing day. * Requirement for uninterrupted use of any medication with actions that might, in the opinion of the involved investigator, confound interpretation of study results.