Ultra Low Dose CT for CACS and AC of SPECT

University of Zurich105 enrolled

Overview

The aim of the study is to compare the CACS obtained from standard dose CT to the CACS obtained from ultra-low-dose scans. Additionally, the usefulness of ultra-low-dose CT for AC of myocardial perfusion SPECT will be assessed.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

105

Conditions

Coronary Artery Disease

Interventions

Ultra low dose non-contrast enhanced CTDEVICE

Non-contrast enhanced CT for CACS and AC using a novel protocol for ultra low dose radiation dose exposure

Standard dose non-contrast enhanced CTDEVICE

Clinically indicated non-contrast enhanced CT for CACS and AC according to routine protocol

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients referred for myocardial perfusion SPECT * Male and Female subjects ≥18 years of age, * Written informed consent Exclusion Criteria: * Pregnancy or breast-feeding * CACS of 0 after inclusion of 10 patients with CACS 0 * Stents or implanted cardiac devices (valves, pace makers, ICD) * Coronary artery bypass grafts

Locations (1)

Department of Nuclear Medicine, University Hospital Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Agreement and Correlation of Coronary Artery Calcium Score Obtained From Ultra-low-dose and Standard CT

CAC and BA limits of agreement between coronary artery calcium score obtained from ultra-low-dose and standard CT. Coronary artery calcium (CAC) is a measure for quantification of coronary artery calcification based on non-contrast enhanced CT, ranging from 0 (no calcifications) to infinite. It is an arbitrary unit. Increasing CAC means higher amounts of coronary artery calcifications and is associated with worse prognosis. Bland-Altman (BA) analysis is a statistical method to compare two modalities or techniques assessing the same measure. Limits of agreement is defined as +/- twice the standard deviation of the differences between the reference method and the new modality/technique. Broader limits of agreement mean less accurate results obtained by the new modality/techniqe, while a 0 BA limit of agreement would theoretically reflect perfect agreement.

Time frame: 1 days

Intra-class Correlation Coefficient Between Segmental Relative Tracer Uptake From SPECT Datasets Reconstructed With AC Maps Based on Ultra-Low-Dose and Standard Dose CT

For every patient, the CT images from 120 and 70 kVp-CT scans were used to create CTAC maps which were then used to reconstruct SPECT images, displayed as a 17-segment model polar plot with normalized percent tracer uptake given for every segment. Intra-class correlation was then applied to compare segmental relative tracer uptake. Analysis and the resulting correlation coefficient of 0.987 basically demonstrates interchangeability between the two datasets.

Time frame: 1 day

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.