This study evaluates the impact of a supervised 12-week high-intensity aerobic interval exercise program (versus a self-directed exercise usual care group) on traditional and novel cardiovascular disease risk factors and surrogate markers of cardiovascular- and overall-mortality in a population-based sample of testicular cancer survivors.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
63
See arm/group description
Peak aerobic capacity (relative VO2peak)
ml O2/kg/min
Time frame: Baseline and within 7 days of completing the 12-week intervention
Peak aerobic capacity (absolute VO2peak)
L/min
Time frame: Baseline and within 7 days of completing the 12-week intervention
Postexercise 1-minute heart rate recovery
change in beats/min
Time frame: Baseline and within 7 days of completing the 12-week intervention
Heart rate
beats/min
Time frame: Baseline and within 7 days of completing the 12-week intervention
Systolic blood pressure
mmHg
Time frame: Baseline and within 7 days of completing the 12-week intervention
Diastolic blood pressure
mmHg
Time frame: Baseline and within 7 days of completing the 12-week intervention
Respiratory sinus arrhythmia
beats/min
Time frame: Baseline and within 7 days of completing the 12-week intervention
Average carotid intima-media thickness
mm
Time frame: Baseline and within 7 days of completing the 12-week intervention
Maximal carotid intima-media thickness
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mm
Time frame: Baseline and within 7 days of completing the 12-week intervention
Carotid distensibility
10-3/kPa
Time frame: Baseline and within 7 days of completing the 12-week intervention
Carotid diameter
mm
Time frame: Baseline and within 7 days of completing the 12-week intervention
Brachial flow-mediated dilation
percent dilation
Time frame: Baseline and within 7 days of completing the 12-week intervention
Brachial diameter
mm
Time frame: Baseline and within 7 days of completing the 12-week intervention
Velocity time integral
cm
Time frame: Baseline and within 7 days of completing the 12-week intervention
Shear stress during reactive hyperemia
dynes/cm2
Time frame: Baseline and within 7 days of completing the 12-week intervention
Carotid-femoral pulse wave velocity
m/s
Time frame: Baseline and within 7 days of completing the 12-week intervention
Femoral-toe pulse wave velocity
m/s
Time frame: Baseline and within 7 days of completing the 12-week intervention
Fibrinogen
g/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
High-sensitivity C-reactive protein
mg/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
Total cholesterol
mmol/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
High-density lipoprotein
mmol/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
Low-density lipoprotein
mmol/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
Total cholesterol : high-density lipoprotein ratio
ratio
Time frame: Baseline and within 7 days of completing the 12-week intervention
Triglycerides
mmol/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
Fasting glucose
mmol/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
Testosterone
nmol/L
Time frame: Baseline and within 7 days of completing the 12-week intervention
Framingham Risk Score
10 year CVD risk %
Time frame: Baseline and within 7 days of completing the 12-week intervention
Vascular age
years
Time frame: Baseline and within 7 days of completing the 12-week intervention
Modifiable CVD Risk Factor Score
Number (max 24)
Time frame: Baseline and within 7 days of completing the 12-week intervention