Gastrointestinal Transit Time in Patients With Guillain-Barré Syndrome

University of Aarhus

Overview

Constipation is a common condition among patients with Guillain-Barré Syndrome. It is believed, that the constipation is caused by autonomic neuropathy. However, the severity of the constipation, and its relation to autonomic function have not previously been studied.

Study Type

OBSERVATIONAL

Conditions

Guillain-Barre Syndrome Constipation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 79 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Guillain-Barré Syndrome * Ability to swallow the capsules used to assess GITT * Ability to give meaningful informed consent to participate in the study Exclusion Criteria: * Major abdominal disorders * Severe acute comorbidity * Known cancer * Pregnancy * Other known neurological disorder * Use of laxatives one week before inclusion. (Patients will be excluded if medication with laxatives is started during the one week GITT measurement)

Locations (1)

Aarhus University Hospital

Aarhus C, Denmark

Outcomes

Primary Outcomes

Gastrointestinal transit time (GITT) [in days]

Time frame: The measurement takes one week to perform. The investigators aim to start the measurement within one week after diagnosis.

Secondary Outcomes

Association between heart rate variability (HRV) and GITT

Linear regression with GITT as dependent variable, and high frequency power spectral density analysis of the heart rate (HF) as the independent variable. The mean HF of the first and second HRV measurement is used for this regression.

Time frame: The first HRV measurement is performed within one week after diagnosis. The second is performed 7 days after the first.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.