Transcranial Direct Current Stimulation for Post-Stroke Aphasia

Columbia University2 enrolled

Overview

This is a randomized, crossover design trial that will compare how anodal transcranial direct current stimulation (tDCS) versus sham tDCS administered during multiple sessions of scripting therapy affects the acquisition and retention of trained scripts.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Stroke

Interventions

Aphasia therapyBEHAVIORAL

Aphasia therapy using a computerized scripting program

Anodal tDCSDEVICE

Anodal transcranial direct current stimulation using the Chattanooga Ionto device

Sham tDCSDEVICE

Sham transcranial direct current stimulation using the Chattanooga Ionto device

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age over 21 years 2. Ischemic left hemispheric stroke verified by imaging (CT or MRI) greater than 6 months ago 3. Residual non-fluent or anomic aphasia, with Western Aphasia Battery-Revised Aphasia Quotient score \<60 4. Fluent English speaker prior to stroke 5. Right-handed prior to stroke 6. Ability to give informed consent and understand the tasks involved. Exclusion Criteria: 1. History of recurrent stroke, either ischemic or hemorrhagic, in the left middle cerebral artery territory 2. Imaging unavailable 3. Large middle cerebral artery infarct involving entire inferior division (temporo-parietal) territory 4. History of dementia prior to the stroke 5. History of seizure, prior electroconvulsive therapy, deep brain stimulators, or brain surgery 6. Social and/or personal circumstances that interfere with ability to return for therapy and assessment sessions.

Locations (1)

Adler Aphasia Center

Maywood, New Jersey, United States

Outcomes

Primary Outcomes

Change in Percent Correct of Trained Scripts

Time frame: From Baseline to up to 2 days post-training

Change in Words Per Minute of Trained Scripts

Time frame: From Baseline to up to 2 days post-training

Secondary Outcomes

Change in Percent Correct of Trained Scripts

Time frame: Baseline to 2 weeks and 4 weeks post-training

Change in Words Per Minute of Trained Scripts

Time frame: Baseline to 2 weeks and 4 weeks post-training

Data from ClinicalTrials.gov

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