Irreversible Electroporation Ablation for Colorectal Metastases to the Lung

Memorial Sloan Kettering Cancer Center2 enrolled

Overview

The investigators are investigating the use of a new cancer treatment called Irreversible Electroporation (IRE). This treatment delivers electrical energy between two needles placed in a cancer. The electrical energy causes cells to die. While this has been used in patients for different applications, the investigators are trying to understand how safe and well it works in colon cancer that has spread to the lung. Once the irreversible electroporation procedure is completed during the operation, the surgeon will then remove the cancer according to standard procedure. As part of the study, they will be measuring safety of the electrical energy delivered and will be reviewing the resected specimen under the microscope.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Colorectal Metastases to the Lung

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed Colorectal cancer with oligometastatic colorectal cancer in the lung * Lung lesion size is greater than 1 cm * Patient will undergo surgical resection as per consultation with their thoracic surgeon and medical oncologist * Patient is cleared to undergo paralytic anesthesia. * Patients 18 years old and older Exclusion Criteria: * Patients with history of cardiac dysrhythmia * Known heart failure (EF \< 40%) * Pacemaker/defibrillator * Patient's with any metallic cardiac implant * Patient on anti-coagulation therapy and are unable to stop therapy for the perioperative period * Women who are pregnant and/or nursing

Locations (4)

Memorial Sloan-Kettering at Basking Ridge

Basking Ridge, New Jersey, United States

Memorial Sloan-Kettering Cancer Center @ Suffolk

Commack, New York, United States

Memorial Sloan Kettering West Harrison

Harrison, New York, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Outcomes

Primary Outcomes

The Frequency of Adverse Events

Safety will be measured by using the NCI Common Terminology Criteria for Adverse Events (CTCAE v4.0). The goal of this study is to establish safety. If there are 3 or more grade 3 or higher device related AEs, then we will stop the study.

Time frame: 2 years