Efficacy and Safety Study of TJCS for Treatment of Moderate to Severe Dry Eye Syndromes

Inclusion Criteria: * Male or female, age 20 or over * Patients with moderate to severe dry eye * Screening both eyes, the corrected visual acuity is 0.2 or more Exclusion Criteria: * Screening visits within 4 weeks who treated with systemic cyclosporine or topical cyclosporine ophthalmic solutions. * Screening visits within 2 months the patients with systemic or ocular disorders affected the test results (ocular surgery, trauma, or disease) * Intraocular pressure(IOP)\> 25 mmHg * Patient using or to use punctual plug within 1 months. * Patients with contact lens.