Combination of Hemodialysis With Hemoperfusion：A Clinical Study

Inclusion Criteria: 1. Age≥18, male or female 2. Maintenance hemodialysis duration\>3 months 3. Regular hemodialysis,3 times a week,4 hours per session 4. Vascular access unlimited 5. iPTH≥300pg/ml 6. Sign the written informed consent Exclusion Criteria: 1. Allergic to dialysis equipment 2. PLT\<60×10\^9/L 3. Blood flow\<200ml/min 4. Serum albumin\<30g/L 5. Kt/V\<1.2 6. iPTH\>800pg/ml 7. Hemodiafiltration 8. Coagulation disorder, severe bleeding tendency, with active bleeding 9. Severe hypotension, severe cardiopulmonary insufficiency 10. Under other drug trial 11. Acute infection, severe heart, lung, liver, nervous diseases, malignant tumor