Recent evidence suggested that the anterior insula cortex seems to be the main site of interoception. Several studies showed an association between change in insula function and interoception, bodily perception and consciousness in subjects with chronic pain. Although osteopathic research has been demonstrated to be effective in reducing pain, studies exploring the effect of osteopathy on interoception are lacking. Therefore, the aim of the present study is to explore the extent to which osteopathic treatment could modify interoception parameters both measuring brain functional connectivity and clinical questionnaires.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
University of Chieti-Pescara
Chieti, Italy
functional connectivity on right anterior insula cortex
before-after change in fMRI values
Time frame: 4 weeks
differences on salience network activities
report any change between study and control group on pattern activation of salience network
Time frame: 4 weeks
acute changes on salience network
voxel differences
Time frame: 2 hours
resting state network differences between groups
voxel differences
Time frame: 4 weeks
DTI changes between groups
differences in DTI parameters and indexes
Time frame: 4 weeks
changes in GABA concentration
amount of GABA in the given voxel
Time frame: 4 weeks
changes in quality of life
SF-36v2 self-reported questionnaire
Time frame: 4 weeks
changes in perception of pain
McGill self-reported questionnaire
Time frame: 4 weeks
changes in disability
Oswestry disability questionnaire
Time frame: 4 weeks
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changes in depression symptoms
Beck Depression Inventory questionnaire
Time frame: 4 weeks
changes in anxiety symptoms
Hospital Anxiety and Depression Scale questionnaire
Time frame: 4 weeks