Intrapleural Cryotherapy for Malignant Pleural Mesothelioma

Inclusion Criteria * Subject provides informed consent * Subject is \>18 years of age * Subject is deemed competent for making medical decisions * Subject is scheduled to undergo pleuroscopy as part of their standard care for pre-operative clinical staging of malignant pleural mesothelioma * A negative pregnancy test is required in women of child-bearing potential, as standard of care. * Subject is mentally capable of understanding study procedures. Exclusion Criteria Study subject has any disease or condition that interferes with safe completion of the study including: * Platelet count \< 50K, coagulopathy defined as an International Normalized Ratio (INR) \> 1.5 * Anticoagulants such as clopidogrel, heparin, low-molecular weight heparin, warfarin or other novel anticoagulants have not been held for the standard time period published * Hemodynamic instability with systolic blood pressure \<90 mmHg or heart rate \> 120 beats/min, unless deemed to be stable with these values by the surgical or interventional pulmonary attending physicians. * Hypoxemia with pulse oximetry values \<88% or partial pressure of oxygen in arterial blood (PaO2) \< 60 on baseline oxygen requirements. * Concurrent participation in another study involving investigational drugs or investigational medical devices * Absence of or limited access to the pleural space during medical pleuroscopy. * Inability to read and understand the necessary study documents.