Correlation Analysis Between Brain Lesions and Sensorimotor Impairments in Individuals With Stroke (Preliminary Study)

University of Minnesota16 enrolled

Overview

The objective of the preliminary study is: 1. To identify correlations between brain lesions and sensorimotor impairments in stroke. 2. To identify possible patterns between brain lesions and sensorimotor impairments that might increase our understanding in stroke recovery and guide further tailor-based neuro-rehabilitation

The purpose of this study is to investigate arm and hand function after stroke and how the location of the brain lesion affects arm and hand function. We are hoping to collect data in the form of assessments what you feel and how your arm moves, surveys about activities in daily life and well-being, and we will perform 1 Magnetic Resonance Imaging (MRI) scan. MRI scans are loud but painless; nothing is injected. With MRI, we collect images from the brain.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Stroke

Interventions

Device: 3T scanner with MRI-compatible robotOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Inclusion criteria for healthy subjects are: * medically stable; * 18 - 99 years of age; * able to hear the instructions given during the study Inclusion criteria for stroke patients are: * at least 6 months post-stroke; * medically stable; * 18 - 99 years of age; * subcortical or cortical infarct confirmed with MRI; * Mini-mental State Exam \> 24/30 (Folstein et al., 1975); * able to hear the instructions given during the study; * able to comprehend the instructions given during the study; * able to commit time to participate in a 6-12-weeks rehabilitation program Exclusion Criteria: Exclusion criteria for healthy subjects are: * having ever experienced a stroke or another brain injury or illness related to the brain that has lasting effects or effects experienced at the moment of recruitment; * severe sensory impairments such that different movements of the finger, hand or wrist are not reliably felt; * contractures in tested arm that hinder persons from keeping the outstretched arm in a relaxed position; * interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy); * exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal parts in the body etc); * pregnant or nursing mother; * adults lacking capacity to consent Exclusion criteria for stroke patients are: * insular or cerebellar infarcts/brain lesions; * unilateral spatial neglect, identified by a standard neuropsychological assessment (Bell's test (score/35, Gauthier et al., 1989); * aphasia; * apraxia (TULIA, Vanbellingen et al., 2011); * severe sensory impairments such that different movements of the finger, hand or wrist are not reliably felt; * contractures in the hemiplegic arm that hinder patients from keeping the outstretched arm in a relaxed position; * interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy); * patients currently receiving therapy for their hemiplegic arm, the latter in order to avoid confounding treatment effects; * exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal parts in the body etc); * pregnant or nursing mother; * adults lacking capacity to consent

Locations (1)

University of Minnesota Medical Center

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Structural and Functional Imaging

Identify correlations between brain lesions and sensimotor impairments in stroke

Time frame: 1 week

Identify Possible Patterns

Identify possible patterns between brain lesions and senosrimotor impairments that might increase our understanding in stroke recovery and guide further tailor-based neuro-rehabilitation

Time frame: 1 week

Data from ClinicalTrials.gov

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