Vitamin d Levels in Children With Bacterial Meningitis

Gang Liu50 enrolled

Overview

The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.

Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis. in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bacterial Meningitis

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Probable bacterial meningitis patients: Clinical manifestation (Any person with sudden onset of fever (\> 38.5 °C rectal or 38.0 °C axillary) and one of the following signs: neck stiffness, altered consciousness or other meningeal sign) with cerebrospinal fluid examination showing at least one of the following: A. turbid appearance; B.leukocytosis (\> 100 cells/mm3); C.leukocytosis (10-100 cells/ mm3) AND either an elevated protein (\> 100 mg/dl) or decreased glucose (\< 40 mg/dl) * Confirmed bacterial meningitis patients: A case that is laboratory-confirmed by growing (i.e. culturing) or identifying (i.e. by Gram stain or antigen detection methods) a bacterial pathogen (Hib, pneumococcus or meningococcus) in the cerebrospinal fluid or from the blood in a child with a clinical syndrome consistent with bacterial meningitis Exclusion Criteria: * Congenital immunodeficiency patients * HIV patients * Patients with corticosteroid treatment for long time * Patients with disorders in adrenal gland and pituitary gland and hypothalamus * Patients with tuberculosis

Outcomes

Primary Outcomes

vitamin d level change

Serum vitamin d level will be detected in the first day of hospitalization and twenty-eighth day of hospitalization, no vitamin d supplementation during this time

Time frame: change in serum vitamin d level from baseline to 28 days after initial hospitalization

Secondary Outcomes

Clinical assessment of disease severity with Glasgow score

Disease severity will be assessed with Glasgow score in the first day of hospitalization

Time frame: 1 day

Clinical assessment of disease severity with Glasgow score

Disease severity will be assessed with Glasgow score in the seventh day of hospitalization

Time frame: 7 day

Clinical assessment of disease severity with Glasgow score

Disease severity will be assessed with Glasgow score in the twenty-eighth day of hospitalization

Time frame: 28 day

Clinical assessment of disease severity with pediatric critical illness score

Disease severity will be assessed with pediatric critical illness score in the first day of hospitalization

Time frame: 1 day

Clinical assessment of disease severity with pediatric critical illness score

Disease severity will be assessed with pediatric critical illness score in the seventh day of hospitalization

Time frame: 7 day

Clinical assessment of disease severity with pediatric critical illness score

Disease severity will be assessed with pediatric critical illness score in the twenty-eighth day of hospitalization

Data from ClinicalTrials.gov

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