The purpose of the study is to determine if a dynamic embryo microenvironment impacts embryo development and reproductive potential in comparison to static culture.
The proposed research design is a prospective randomized control trial. Patients with normal ovarian reserve, who would be expected to have reasonable outcomes after in vitro fertilization, will serve as the subjects. Embryos from the same patient will be randomized to either static or dynamic culture. They will then be cultured to the blastocyst stage of embryo development and biopsied for preimplantation genetic screening. The best chromosomally normal embryo from each culture group will be selected and transferred to complete a double embryo transfer in a subsequent frozen embryo transfer cycle the following month.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
200
Patients will have their cohort of embryos split in half. Half will be cultured in the dynamic platform and the other half cultured in static.
Reproductive Medicine Associates of New Jersey
Basking Ridge, New Jersey, United States
Blastulation Rate
the number of blastocysts will be counted
Time frame: 6 days post vaginal oocyte retrieval procedure
Clinical Pregnancy Rate
documented intrauterine pregnancy
Time frame: approximately 20-25 days post embryo transfer procedure
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